From the earliest days of coronavirus 2019 (COVID-19) outbreaks, all countries have been trying to develop vaccines and medications to fight the virus. Finally, a year after the COVID-2019 pandemic, several companies developed vaccines that were safe against this disease. However, the lack of doses of these vaccines created problems for various countries. Ethically, some groups should be highly prioritized according to their need and necessity of receiving the vaccine. Based on the results of current studies, safe and effective vaccination can be effective for the elderly and patients with chronic diseases and prevent the death of such people extensively. Since the national vaccination in Iran has started on February 12, 2021, with the priority of the medical staff, it is necessary to pay more attention to the elderly and patients with chronic diseases in future planning regarding the COVID-19 vaccination.