Volume 25, Issue 4 (January 2018)
J Birjand Univ Med Sci. 2018, 25(4): 286-296 |
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Shafei Z, Abbasi Maleki S, Ghaderi-Pakdel F. Evaluation of the antidepressant-like effect of Viola odorata hydroalcoholic extract in male mice. J Birjand Univ Med Sci. 2018; 25 (4) :286-296
URL: http://journal.bums.ac.ir/article-1-2484-en.html
URL: http://journal.bums.ac.ir/article-1-2484-en.html
1- Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran.
2- Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran. , s.abbasi@iaurmia.ac.ir
3- Department of Physiology, Urmia University of Medical Science, Urmia, Iran.
2- Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran. , s.abbasi@iaurmia.ac.ir
3- Department of Physiology, Urmia University of Medical Science, Urmia, Iran.
Abstract: (5650 Views)
Background and Aim: In traditional medicine Viola odorata (VO) has been used as anti-inflammatory, hypnotic, sedative, antioxidant, anti-anxiety, and therapist for neuropsychiatric disorders; Hence, in the present study, the antidepressant effect of VO hydroalcoholic extract in mice was investigated.
Materials and Methods: In this experimental study, one hundred-fourteen male albino mice were randomly divided into normal saline or control (10ml/kg, i.p), fluoxetine (20mg/kg, i.p), imipramine (30mg/kg, i.p) and, VO extract (50, 100, 200, 400 mg/kg, i.p), respectively. The antidepressant-like activity was performed by behavioral tests as forced swimming test (FST), tail suspension test (TST), and open field test.
Results: The VO extract (100 to 400 mg/kg) reduced immobility time in both FST and TST (P<0.01 and P<0.001, respectively). The extract increased swimming time (P<0.01 and P<0.001, respectively) without significant change of climbing time (P>0.05). In OFT, doses of 200mg / kg and 400mg / kg of VO caused the reduced the number of crossings from the square and on the two feet (P <0.05 and P <0.01 respectively).
Conclusion: Probably, the acute doses of the Viola odorata, similar to fluoxetine, are likely to cause anti-depressant effects.
Materials and Methods: In this experimental study, one hundred-fourteen male albino mice were randomly divided into normal saline or control (10ml/kg, i.p), fluoxetine (20mg/kg, i.p), imipramine (30mg/kg, i.p) and, VO extract (50, 100, 200, 400 mg/kg, i.p), respectively. The antidepressant-like activity was performed by behavioral tests as forced swimming test (FST), tail suspension test (TST), and open field test.
Results: The VO extract (100 to 400 mg/kg) reduced immobility time in both FST and TST (P<0.01 and P<0.001, respectively). The extract increased swimming time (P<0.01 and P<0.001, respectively) without significant change of climbing time (P>0.05). In OFT, doses of 200mg / kg and 400mg / kg of VO caused the reduced the number of crossings from the square and on the two feet (P <0.05 and P <0.01 respectively).
Conclusion: Probably, the acute doses of the Viola odorata, similar to fluoxetine, are likely to cause anti-depressant effects.
Type of Study: Original Article |
Subject:
Pharmacology
Received: 2018/04/28 | Accepted: 2018/09/17 | ePublished: 2018/12/15
Received: 2018/04/28 | Accepted: 2018/09/17 | ePublished: 2018/12/15
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