Background and Aim: 
Drug prescription is an important part of pharmacotherapy; therefore, inattention to the principle of drug prescription can cause problems such as incorrect treatment, unsuccessful or incomplete, and force higher cost to patients and society. While prescribing and rational use of drugs can prevent the loss of national capital and community health promotion through improving the quality of life. the goal of this study was to investigate the prescribing indicators of South Khorasan province to determine the level of  rational use of drugs.
Materials and Methods: 
In this study, drug prescription data from specialists and general physicians collected from insurance company and analyzed by Rx-analyzer software. Prescibing indicators of all physicians were extracted and evaluated in seprate groups.
Results: 
This study has been done on 1,423,642 insured drug prescriptions collected in South Khorasan province. Indicators showed average number of drug per medical prescription 2.89, the percentage of injectable drugs prescription 33%, the percentage of antimicrobial drugs prescription 42%, the percentage of corticosteroids drugs prescription 20% and precentage of medication prescribed more than 4 drugs 12% were obtained. Also most commonly prescribed drugs to patients are as corticosteroids and antibiotics.
Conclusion: 
Higher drug prescription indicators of South Khorasan especially on corticosteroids and antibiotics percentage in comparison to global data emphasis scientific and educational interventions to promote the principle of rational use of drug.