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malekaneh M, esmaeili S, fallah pour amiry M, tane G, hemmati M. The effect of aqueous extract of the plant eryngium campestre on prevention of pathologic alterations caused by the calcium oxalate crystals induced by ethylene glycol in cortex and medulla of renal in rats. J Birjand Univ Med Sci.. 2017; 24
URL: http://journal.bums.ac.ir/article-1-2238-en.html

1- Assistant Professor , drmalekaneh@yahoo.com
2- student
3- Assistant Professor
Abstract:   (464 Views)

           

              Abstract

Background and Aim

Due to the effects of medicinal plants in the prevention of kidney stones, the purpose of this study The effect of aqueous eryngium campestre on prevention pathologic alterations caused by the calcium oxalate crystals induced by ethylene glycol in cortex and medulla of renal in rats.


Analysis method

In this study, 40 male Wistar rats weighing in the range 200 – 250 gr randomly into 5 groups of 8 animals were divided evenly and consist healthy control group that just received water, negative control group that received water with 1% ethylene glycol, prevention groups in addition to 1% ethylene glycol in water daily gavaged with 100mg/kg , 200mg/kg and 400mg/kg of plant extract. After 30 days all rats were killed and were prepared slides from each kidney. Slides were staining with H/E method and number of calcium oxalate crystals was checked


RESULTS


The results show that there is a significant difference between the control health and negative groups (p˂0.05). Prevention group with dose 100 mg/kg despite reducing the numbers of crystals compared to the negative groups, there was no significant difference with this group (p˃0.05). As well as the prevention group dose 200mg/kg compared to the negative control group there was significant difference in reducing the number of crystals (p˂0.05). But in the prevention group dose 400mg/kg there was no significant difference with negative control group (p˃0.05).

Conclusion



The results of this study showed that aqueous extract of eryngium campestre had been effective in prevent accumulation of calcium oxalate crystals in the kidney. So that, indicative decrease of calcium oxalate crystals in prevention group with dose 200 mg/kg.

     
Type of Study: Original Article | Subject: Biochemistry
Received: 2017/02/9 | Accepted: 2017/04/10 | Published: 2017/04/12

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