Volume 22, Number 3 (October 2015)                   J Birjand Univ Med Sci. 2015, 22(3): 209-217 | Back to browse issues page


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Foroozandeh M, Bigdeli M R, Rahnema M. The effect of pre-nutrition of hydroalcoholic extractof Origanum vulgare on brain edema and neurologic deficits in a rat stroke model. J Birjand Univ Med Sci.. 2015; 22 (3) :209-217
URL: http://journal.bums.ac.ir/article-1-1862-en.html

1- MSc in Physiology, Biology Research Center, Department of physiology, Zanjan-Branch, Islamic Azad University of Zanjan, Zanjan, Iran
2- Associate Professor, Shahid Beheshti University, Faculty of Biological Science, Assistant Professor of Physiology, Tehran, Iran.
3- Associate Professor, of Physiology, Biology research center, Department of physiology, Zanjan-Branch, Islamic Azad University of Zanjan, Zanjan, Iran , meh_rahnema@yahoo.com
Abstract:   (3290 Views)

Background and Aim: Stroke is one of the most important factors of mortality and disability in the world. Free radicals are produced following ischemic stroke and they play a central role in breaking the blood-brain barrier and  causing brain edema formation.

The aim of the current study was to evaluate the effect of hydro- alcoholic extract of Origanum vulgare on brain edema and neurologic deficit in a rat stroke model.

Materials and Methods: In thisexperimental study, 35 male Wistar rats were randomly divided into 5 equal groups.  The first  two groups (control and Sham)) received distilled water, while three treatment groups received oral Origanum vulgare extract for 30days (50,75and 100 mg/kgdaily, respectively).  Two hours after the last dose of Origanum vulgare extract,each main group underwent  a 60 min middle cerebral artery occlusion.  Then, the assessment of blood brain edema, and neurologic deficits analysis were done . Brain edema (brain water content) was analyzed by One-Way ANOVA using LSD method and neurologic deficits analysis by means of Mann-Whitney U, and P<0.05 was taken as the significant level.

Results: Origanum vulgare extract reduced brain edema in the experimental groups of 50 (82.49±0.47), 75 (80.89±0.63) and 100 mg/kg/day (80.80±0.66) compared to the control group (84.46±0.67). The neurologic deficit scores in the experimental groups of 75and 100mg/kg/day, compared with control group, but neurologic deficit scores did not affect the group receiving the dose 50 mg/kg.

Conclusion:  The obtained data indicate that Origanum vulgar extract via reduction of brain edema and neurologic deficits scorescan have a protective effect on the stroke model.

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Type of Study: Original Article | Subject: Physiology
Received: 2015/04/30 | Accepted: 2015/09/15 | Published: 2015/11/18

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