Volume 21, Number 3 (October 2014)                   J Birjand Univ Med Sci. 2014, 21(3): 394-400 | Back to browse issues page


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Jasemi S S, Alipoor F, Dehbashi S, Mardaneh J. Isolation of Citrobacter spp. from Blood Specimens in Patients Hospitalized in Kermanshah Imam Khomeini hospital .. and determination of the of isolates sensitivity to antibiotics: Short Communication. J Birjand Univ Med Sci.. 2014; 21 (3) :394-400
URL: http://journal.bums.ac.ir/article-1-1622-en.html

1- Postgraduate in Medical Microbiology, Department of pathobiology, Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. , somayejasemy@yahoo.com
2- Laboratory Technician, Medical Microbiology Laboratory, Emam Khomeni Hospital, Kermanshah, Iran
3- Postgraduate in Medical Microbiology, گروه پاتوبیولوژی، بخش میکروب‌شناسی، دانشکده بهداشت، دانشگاه علوم پزشکی تهران، تهران، ایران
4- Assistant Professor in Medical Bacteriology, Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract:   (4529 Views)
Background and Aim: Citrobacter is a gram-negative, nonsporeforming, facultative anaerobic and motile bacillus within the family of Enterobacteriaceae and is ubiquitous in nature. This opportunistic pathogen causes a wide spectrum of infections. The aim of the present study was to examine the isolation of Citrobacter spp. from blood specimens in patients hospitalized in Kermanshah Imam Khomeini hospital and to determine the isolates sensitivity to antibiotics. Materials and Methods: This cross- sectional study was carried out on 2285 blood specimens collected from hospitalized patients between March 2012 and February 2012. In the beginning, the blood samples were inoculated in blood culture tubes media. The Citrobacter spp. isolates were identified and their identification was confirmed by means of morphological and biochemical laboratory tests. Drug sensitivity test was carried out according to CLSI (2011) recommendations through using the standard disc diffusion method. Results: In this study Citrobacter spp. were isolated from 21 (15.8%) of 133 culture positive blood specimens collected from the hospitalized patients. The most effective antimicrobial agents against Citrobacter isolates were imipenem (90.4%), and amikacin (71.5%), respectively. The most frequent resistance observed was to cephalothin (76.2%), ciprofloxacin (76.2%), ceftazidime (66.6%) and co-trimoxazole (62%). Conclusion: Citrobacter isolates showed high resistance to betalactam antibiotics. Therefore, it is necessary that these drugs should only be administered to patients whose diagnostic isolates reveal sensitivity in vitro.
Full-Text [PDF 285 kb]   (1870 Downloads)    
Type of Study: Original Article | Subject: Microbiology
Received: 2014/04/29 | Accepted: 2014/10/15 | Published: 2014/12/1

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