Volume 21, Number 1 (April 2014)                   J Birjand Univ Med Sci. 2014, 21(1): 35-47 | Back to browse issues page


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Mohammadi Karizno F, Saghebjoo M, Foadoddini M, Sarir H. The role of aerobic training and Pistacia atlantica extract on the levels of protein carbonyl, heat shock protein 70, and glycogen in the liver tissue of diabetic rats. J Birjand Univ Med Sci.. 2014; 21 (1) :35-47
URL: http://journal.bums.ac.ir/article-1-1577-en.html

1- M.Sc of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Birjand, Birjand, Iran;
2- Associate Professor of Exercise Physiology , Department of Physical Education, Faculty of Physical Education and Sport Sciences, University of Birjand, Birjand, Iran , m_saghebjoo@birjand.ac.ir
3- Assistant Professor of Physiology, Atherosclerosis and Coronary Heart Research Center, Birjand University 0f Medical Sciences , Birjand, Iran;
4- Assistant professor of Immunology, Faculty of Agriculture, University of Birjand, Birjand, Iran.
Abstract:   (10936 Views)
Background and Aim: The use of medicinal herbs is taken as a healthy and effective alternative treatment for hyperglycemia and liver toxicity. Therefore, due to the positive effects of exercise training on diabetic patients, the objective of the present study was to investigate the effect of a 6 week period of aerobic training together with Pistacia atlantica extract taking on protein carbonyl (PC), heat shock protein 70 (HSP70) , and glycogen levels in the liver tissues of diabetic rats. Materials and Methods: In this experimental research, 40 male Wistar rats were randomly divided into 5 groups: 1) healthy control, 2) diabetic control, 3) diabetic under aerobic training, 4) diabetics receiving Pistacia atlantica extract and 5) diabetics under aerobic training and receiving the extract. .The six week period exercise program included aerobic training on a treadmill (5 sessions per week, 40 minutes per each session, with a speed of 20m/min and 5% incline). Pistacia atlantica extract was fed 5 days per week (25mg/kg). The rats were anesthetized.48 hours after the last training session, and their livers were isolated. Then, the level of their PC, HSP70, and hepatic glycogen were assessed by means of ELISA and chemical colorometry. Results: Mean level of PC in the diabetic group under aerobic training, diabetic group receiving pistacia extract, and the group under aerobic training together with receiving pistacia extract was significantly lower than that of the control diabetic group (P was 0.002,0.006 and 0.002, respectively) but, mean level of PC was not significantly different in the three case groups. Mean level of HSP70 and glycogen in the three groups was not significantly different either (P was 0.21 and 0.59 ,respectively). Conclusion: It was found that aerobic training and Pistacia atlantica extract consumption, either alone or together, led to a significant reduction in PC levels in the liver tissues of diabetic rats. Thus, Pistacia atlantica extract and aerobic training can be good remedies in reducing liver complications resulting from diabetes.
Full-Text [PDF 260 kb]   (1768 Downloads)    
Type of Study: Original Article | Subject: Physiology
Received: 2014/02/7 | Accepted: 2014/06/21 | Published: 2014/06/21

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