Background and Aim: Wound healing is a complex and dynamic process with the wound environment changing with the changing health status of the individual. Therefore identification new natural products is necessary for accelerate wound healing. The present study investigated the effect of topical application of Persian Gulf brittle star alcoholic extract on wound healing in Balb/C mice. Materials and Methods: 40 Balb/C mice were divided randomly into 4 groups including: control group, positive control (treatment with honey), negative control (treatment with physiological serum), and experimental group (treatment with extract 1% of brittle star). In all groups in posterial part 1 hole (6 mm in diameter) wound created. On the 3th, 6th, 9th and 12th day after creation wound, samples were collected from the healing hole. Histopathological changes were investigated and analyzed by Spss software and using ANOVA test for repeated measured data with p<0.05. Results: Significant changes in proliferation of inflammatory cells (on the 12th day), epithelium thickness (on the 6th day), more angiogenesis (on the 6th- 9th day), in the experimental wounds were compared with those in the control group. However, experimental group with positive control were not significantly different in these days. Conclusion: Findings of this research indicated that the topical application of brittle star extract posse positive impact on wound healing process.

Keywords: Wound healing, Brittle star (Ophiocoma erinaceus), Persian Gulf, Balb/C

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