Background and Aim: Depression is a commomn common psychiatric disordersdisorder.. The Sever severe form of depression, that callled call.ed as . major depression , has many effects on the mental health of patient's patients. It may even lead to health including. suicidal attempt. Electro Convulsive Therapy (ECT) is still the most effective treatment for major depression. The purpose of this studyis comparison ofof the present study was to compare two anesthetic induction methods: ketamin and thiopental Na for ECT in major depression disorder patients. Materials and Methods: The current study was done as a double blind randomized clinical trial on 60 patients with psychiatric disorders 30 of whom were administered ketamin .and 30 .thiopental Na .. Then, the patients' responses to treatment in the form of energy expenditure, duration of seizures , and the Hamilton Depression Rating Scale(HDRS) were evaluated. The obtained data was analyzed by means of Chi-square and mann-whitney tests using SPSS. Software (V:21).. Results: Rate of depression (ketamin:22.50±5.50 and thiopental Na:30.05 ±7.95 ) and energy expenditure (ketamin: 81.33±3.31 and thiopental Na:85.33 ±11.34 ) was higher in thiopental Na. Changes in rate of depression showed significant difference between the two groups but Changes in energy expenditure showed no significant difference. .. Furthermore, duration of seizures (ketamin:35.46±7.93 and thiopental Na:30.09 ±14.38 ) was higher in ketamin group therefore,the difference was significant ... Conclusion: . Severity of depression and seizure duration changes showed that ketamin is better than thiopental Na. Thus, it seems that ketamin administration can be used as an alternative method of anesthesia in depression patients that candidate for ECT..

Keywords: ketaminKetamin, thiopental Thiopental Na, depressionDepression, Electro Convulsive Therapy

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