Correlation between Serum level of Troponin I and High Sensetive CRP in Renal transplant Patients

Zeraati, Abbas Ali; Sharifipour, Farzaneh; Rajabigol, Faezeh; Pourzand, Hourak; Beladi Mousavi, Seyyed Seifollah

Volume 20, Issue 3 (October 2013) J Birjand Univ Med Sci. 2013, 20(3): 312-316 | Back to browse issues page

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Zeraati A A, Sharifipour F, Rajabigol F, Pourzand H, Beladi Mousavi S S. Correlation between Serum level of Troponin I and High Sensetive CRP in Renal transplant Patients. J Birjand Univ Med Sci. 2013; 20 (3) :312-316
URL: http://journal.bums.ac.ir/article-1-1243-en.html

Correlation between Serum level of Troponin I and High Sensetive CRP in Renal transplant Patients

Abbas Ali Zeraati ^*¹, Farzaneh Sharifipour², Faezeh Rajabigol³, Hourak Pourzand⁴, Seyyed Seifollah Beladi Mousavi⁵

1- Department of Internal Diseases, Kidney Transplantation Complications Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , zeraatia@mums.ac.ir
2- Department of Internal Diseases, Kidney Transplantation Complications Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3- Kidney Transplantation Complications Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
4- Department of Cardiology, faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5- Internal Medicine Department, Chronic Renal Failure Research Center, Ahwaz Jundishapour University of Medical Sciences, Ahvaz, Iran

Abstract: (41252 Views)

Background and Aim: Accompaniment of high serum levels of CRP to troponin increases the mortality rate in dialysis patients, and both of them are considered to be independent risk factors for uremic cardiomyopathy. In the present study, the relationship between serum troponin I and hs-CRP in renal transplant patients was investigated. Materials and Methods: This .study was conducted on 52 patients undergone kidney transplantation. The patients’ serum troponin I and hs-CRP were measured. Clinical characteristics of them including sex, age, duration of disease, and donor type were obtained by their respective medical record review. Spearman’s correlation coefficient method was applied to specify correlation between serum troponin and hsCRP levels. Results: In the current study, 52 patients (27 males and 25 females) with the mean age of 42.98±13.4 yrs were studied. It was found that Hs-CRP levels statistically differed between recipients who had received kidney from deceased and those from live donors. The formers who had received kidney from deceased donors showed significantly higher hsCRP levels compared to recipients from. live donors, but the difference between serum troponin I in the two groups was not significant. There was no significant correlation between serum troponin I and hs-CRP in the total population (p=0.6, r=-0.04), and also in recipients who had received kidney from live or deceased donors. Conclusion: Regarding the insignificant relationship between serum troponin I and hs-CRP in kidney transplant patients, it seems that inflammation has no role on myocardial injury.

Keywords: Troponin I, hs-CRP, Kidney Transplantation

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Type of Study: Original Article | Subject: Surgery of Nephrology
Received: 2012/09/17 | Accepted: 2013/06/19 | ePublished: 2013/12/3