Volume 19, Number 4 (January 2013)                   J Birjand Univ Med Sci. 2013, 19(4): 455-462 | Back to browse issues page


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Omidi A, Torabi Z, Hassanpoorfard M, Zardast M. Evaluation of protective effect of hydroalcoholic extract of Crocus sativus petals on preventing of gentamicin induced peliosis hepatis and hepatic telangiectasis in rats: short communication . J Birjand Univ Med Sci.. 2013; 19 (4) :455-462
URL: http://journal.bums.ac.ir/article-1-1147-en.html

1- associate professor, Cattle health management department, Veterinary school, Shiraz university, Iran , aomidi@shirazu.ac.ir
2- BSc. in veterinary science, veterinary science department, agriculture school, Birjand university, Iran
3- Assistant professor, Pharmacology department, school of medicine, Birjand University of Medical Sciences (BUMS)
4- Assistant professor, Pathology department, school of medicine, Birjand University of Medical Sciences(BUMS)
Abstract:   (11727 Views)
Peliosis hepatis is a rare liver disease characterized by blood-filled cavities scattered irregularly throughout the liver. Risk factors for peliosis include chronic illness such as AIDS, tuberculosis, cancer also use of some drugs such as anabolic steroids and azathioprine. The aim of the present study was to evaluate the curative properties of crocus sativus petals on induced peliosis hepatis in rats. Thirty two male Wistar rats (weight: 180-220 g) were randomly divided into four equal groups: group 1 (healthy group) received only IP normal saline, group2 received IP 80mg/kg.bw gentamicin, group3 IP 80mg/kg.bw gentamicin+ 40mg/kg crocus sativus petal extract, and group 4 was given IP 80mg/kg.bw gentamicin+ 40mg/kg crocus sativus petal extract. At the end of the experiment, the rats were anesthetized and their blood samples were collected through cardiac puncture for AST and ALT measurement.Then, the livers of the subjects were excised and fixed in formalin. It was found that AST significantly increased in gentamicin group (P<0.05) compared to the healthy group and groups treated by means of crocus sativus petal extract .Moreover, there was no significant differences between the groups administered the extract and those given gentamicin. Histologically,heterogeneous multiple blood-filled cavities were observed in gentamicin group (2) and the treatment groups (3 and 4). The results of the present study show that doses of hydroalcoholic extract of crocus sativus do not effect on peliosis hepatic and telangiectasis due to gentamicin sulfate in rats
Full-Text [PDF 383 kb]   (2789 Downloads)    
Type of Study: Original Article | Subject: Pharmacology
Received: 2012/06/29 | Accepted: 2012/12/11 | Published: 2016/03/10

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