Volume 20, Number 1 (April 2013)                   J Birjand Univ Med Sci. 2013, 20(1): 20-28 | Back to browse issues page


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Roghani M, Kiasalari Z, Khalili M, Pesaran F. Effect of acetyl L carnitine on oxidative stress markers in hippocampus of epileptic rat. J Birjand Univ Med Sci.. 2013; 20 (1) :20-28
URL: http://journal.bums.ac.ir/article-1-1123-en.html

1- Professor Neurophysiology Research Center, Shahed University, Tehran, Iran , mehjour@yahoo.com
2- Associate Professor Research Center neurophysiology, Shahed University, Tehran, Iran
3- Professor Center for Traditional Medicine clinical neurophysiology and Research Center, Shahed University, Tehran, Iran
4- Graduated School of Medicine Shahed University, Tehran, Iran
Abstract:   (8504 Views)
 Background and Aim: Epilepsy is a rather common neurological disorder. Oxidative stress plays an important role in the pathogenesis of epilepsy. The present study was undertaken to evaluate the effect of acetyl L carnitine (ALC) on oxidative stress markers in hippocampus of epileptic rat. 

Materials and Methods: In this experimental study, male rats were divided into sham, epileptic, valproic acid-treated epileptic ones at a dose of 200mg/kg, and 3 ALC-treated epileptic groups at doses of 50 and 100mg/kg for 3 days pre-surgery. Seizure activity was determined in 4 h periods and for measurement of oxidative stress markers, level of malondialdehyde (MDA), nitrite, and activity of superoxide dismutase (SOD) were determined in hippocampal homogenate. The obtained datawas fed into SPSS software (V:16) and for statistical analysis, one-way ANOVA and x2 tests were used.

 Results: ALC treatment at doses of 50 and 100 mg/kg attenuated seizure intensity (P<0.05 and P<0.01, respectively), level of MDA significantly reduced (P<0.05) following ALC at a dose of 50 mg/kg, but nitrite level and SOD activity did not show significant changes. 

Conclusion: ALC pretreatment has antiepileptic activity and at a dose of 50 mg/kg can reduce MDA level as an index of lipid peroxidation but it has no appropriate effect on nitrite level and SOD activity.

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Type of Study: Original Article | Subject: Biochemistry
Received: 2012/06/1 | Accepted: 2013/05/15 | Published: 2016/03/10

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