Volume 24, Number 1 (April 2017)                   J Birjand Univ Med Sci. 2017, 24(1): 28-35 | Back to browse issues page


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Zarezadeh M, Dehghani Firoozabadi M, Zarban A, Sharifzadeh G, Valavi M. Vitamin D status among multiple sclerosis patients in South Khorasan: a case-control study. J Birjand Univ Med Sci.. 2017; 24 (1) :28-35
URL: http://journal.bums.ac.ir/article-1-2158-en.html

1- Member of Student Research Committee, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
2- Department of Neurology, Faculty of Medicine, Birjand University of medical science, Birjand, Iran. , mdehghani44@yahoo.com
3- Birjand CardioVascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
4- Social Determinant of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Abstract:   (1720 Views)

Background and Aim: Observational studies have demonstrated that the risk of developing multiple sclerosis (MS) is associated with vitamin D (25(OH)D) status. However, there is no local study regarding vitamin D status in MS patients in the South Khorasan. Therefore, present study aimed at comparing the serum levels of vitamin D between the South Khorasan MS patients and healthy subjects, and determining its association with disability in these patients.

Materials and Methods: In this case-control study a total of 144 individuals (72 previously diagnosed MS cases and 72 age and sex matched healthy controls) were included. Demographic characteristics and serum vitamin D levels of both groups as well as Expanded Disability Status Scale (EDSS) for MS patients were assessed. The obtained data was analyzed using t-test, Mann Whitney U test, Chi-square, and Pearson's correlation coefficient test applying SPSS software.

Results: There was a significant difference (P<0.0001) in vitamin D levels between the case (47.4±5.4ng/mL) and the control (14.66±10.4 ng/mL) groups. A direct association was found between vitamin D levels and EDSS in MS patients (P<0.0001), too.

Conclusion: Surprisingly, it was found that vitamin D level was significantly higher in MS patients than the controls. There was a significant positive association between the level of vitamin D and disability status in patients with MS. The association may be due to more administration of vitamin D supplement to MS patients.

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Type of Study: Original Article | Subject: Epidemiology
Received: 2016/07/25 | Accepted: 2017/01/15 | Published: 2017/06/11

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