Journal of Translational Medical Research
تحقیقات پزشکی ترجمانی
Journal of Translational Medical Research.
Medical Sciences
http://journal.bums.ac.ir
87
journal87
3115-9176
3092-6912
10.61882/JBUMS
fa
jalali
1405
3
1
gregorian
2026
6
1
33
1
online
1
fulltext
en
بروز کمکاری مادرزادی تیروئید در نوزادان متولد شده در سالهای 1402 و 1403 در استان خراسان جنوبی
Incidence of congenital hypothyroidism among newborns in South Khorasan Province: A 2-year study (2023-25)
بهداشت عمومی
General Health
مقاله اصیل پژوهشی
Original Article
<div style="text-align: justify;"><span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="AR-SA" mitra="" style="font-family:"><span style="color:black">زمینه و هدف:</span></span></b><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"> کمکاری مادرزادی تیروئید از شایعترین اختلالات غدد درونریز و از علل مهم و قابل پیشگیری عقبماندگی ذهنی است که در صورت تشخیص و درمان بهموقع، عوارض آن قابل پیشگیری است. این مطالعه با هدف تعیین میزان بروز کمکاری مادرزادی تیروئید در نوزادان استان خراسان جنوبی طی سالهای 1402 و 1403 انجام شد</span></span></span><span dir="LTR" lang="EN-CA" style="font-size:9.0pt"><span style="color:black">.</span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="AR-SA" mitra="" style="font-family:"><span style="color:black">روش تحقیق:</span></span></b><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"> این پژوهش توصیفی گذشتهنگر بر روی تمامی نوزادان متولدشده بین فروردین 1402 تا اسفند 1403 انجام شد. نوزادان با</span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">TSH</span> <span lang="FA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">(</span></span></span><span dir="LTR" style="color:black">Thyroid Stimulating Hormone</span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">) پاشنه پا </span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span arial="" style="font-family:"><span style="color:black">≥</span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">10 در نوبت اول و </span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span arial="" style="font-family:"><span style="color:black">≥</span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">5 در نوبت دوم غربالگری، فراخوان شدند. سپس سطح سرمی </span></span></span><span dir="LTR" lang="EN-CA" style="color:black">TSH</span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">، </span></span></span><span dir="LTR" lang="EN-CA" style="color:black">T4</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">و</span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">T3RU</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">آنها </span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">اندازهگیری شد. نوزادانی با</span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">TSH</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">سرمی </span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span arial="" style="font-family:"><span style="color:black">≥</span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">10</span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">mU/L</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">و</span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">T4</span><span dir="LTR" lang="EN-CA" style="font-size:9.0pt"><span style="color:black"> <6.5 </span></span><span dir="LTR" lang="EN-CA" style="color:black">µg/dl</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">بهعنوان مبتلا به کمکاری مادرزادی تیروئید در نظر گرفته شدند</span></span></span><span dir="LTR" lang="EN-CA" style="font-size:9.0pt"><span style="color:black">.</span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="AR-SA" mitra="" style="font-family:"><span style="color:black">یافتهها:</span></span></b> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">از 30021 نوزاد غربالشده، 1205 نفر (01/4%) فراخوان شدند. در نهایت 152 نوزاد (06/5 در هزار) دارای</span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">TSH</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">سرمی </span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span arial="" style="font-family:"><span style="color:black">≥</span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">10</span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">mU/L</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">و مبتلا به کمکاری تیروئید تشخیص داده شدند. بروز بیماری در سال 1402، 78 مورد (12/5 در هزار) و در سال 1403، 74 مورد (5 در هزار) بود. در غربالگری اولیه نوزادان مبتلا،</span></span></span><span dir="LTR" lang="EN-CA" style="color:black">TSH</span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">پاشنه پادر 98/87% کمتر از 5، در 15/11% بین 5 تا 9/9 و در 87/0% برابر یا بیش از </span></span></span> <span dir="LTR" lang="EN-CA" style="color:black">mU/L</span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">10 </span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black">بود. بروز کلی بیماری 1 در 198 تولد زنده بود</span></span></span><span dir="LTR" lang="EN-CA" style="font-size:9.0pt"><span style="color:black">.</span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"></span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="AR-SA" mitra="" style="font-family:"><span style="color:black">نتیجهگیری:</span></span></b><span lang="AR-SA" style="font-size:11.0pt"><span b="" mitra="" style="font-family:"><span style="color:black"> بروز کمکاری مادرزادی تیروئید در استان خراسان جنوبی بالا است. با توجه به نقش این بیماری در عقبماندگی ذهنی، انجام مطالعات تکمیلی برای شناسایی عوامل مؤثر ضروری به نظر میرسد.</span></span></span></span></span></span></span></div>
<div style="text-align: justify;"><span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><a name="_Hlk200355634"><b><span style="font-size:11.0pt"><span style="color:black">Background and Aims:</span></span></b></a> <span style="font-size:11.0pt"><span style="background:white"><span style="color:black"> Congenital hypothyroidism (CH) is one of the most common endocrine disorders and a major preventable cause of intellectual disability. Its complications can be </span></span></span><span style="font-size:11.0pt"><span style="background:white"><span style="color:black">effectively prevented through timely diagnosis and treatment</span></span></span><span lang="EN-CA" style="font-size:11.0pt"><span style="background:white"><span style="color:black">. </span></span></span> <span style="font-size:11.0pt"><span style="background:white"><span style="color:black">This study aimed to determine the incidence of congenital hypothyroidism among newborns in South Khorasan Province during 2023-25</span></span></span><span style="font-size:12.0pt"><span style="color:black">.</span></span><span style="font-size:11.0pt"></span></span></span><br>
<span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:black">Materials and Methods:</span></span></b> <span lang="EN-CA" style="font-size:11.0pt"><span style="color:black">This retrospective descriptive study included all newborns born between </span></span><span style="font-size:11.0pt"><span style="color:black">March</span></span> <span style="font-size:11.0pt"><span style="color:black">2023</span></span><span lang="EN-CA" style="font-size:11.0pt"><span style="color:black"> and March </span></span><span style="font-size:11.0pt"><span style="color:black">2025.</span></span><span lang="EN-CA" style="font-size:11.0pt"><span style="color:black"> Infants with heel-prick </span></span><span style="font-size:11.0pt"><span style="color:black">thyroid-stimulating hormone (TSH) </span></span><span lang="EN-CA" style="font-size:11.0pt"><span style="color:black">levels ≥10 mU/L in the first screening and ≥5 mU/L in the second screening were recalled for further evaluation. Serum levels of TSH, T4, and T3RU were then measured. Newborns with serum TSH ≥10 mU/L and T4 <6.5 µg/dL were diagnosed as having CH</span></span><span style="font-size:11.0pt"><span style="color:black">.</span></span></span></span><br>
<span style="font-size:10pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:black">Results:</span></span></b><span style="font-size:11.0pt"><span style="color:black"> Out o</span></span><span lang="EN-CA" style="font-size:11.0pt"><span style="color:black">f 30,021 screened newborns, 1,205 (4.01%) cases were recalled. Ultimately, 152 (5.06 per 1,000) infants had serum TSH ≥10 mU/L and were diagnosed with CH. The incidence rate was 78 (5.12 per 1.000 live births) cases in 2023 and 74 (5.0 per 1.000 live births) cases in 2025. In the initial screening of affected newborns, heel-prick TSH was <5 mU/L in 87.98%, between 5–9.9 mU/L in 11.15%, and ≥10 mU/L in 0.87%. The overall incidence of CH was 1 per 198 live births</span></span><span style="font-size:11.0pt"><span style="color:black">.</span></span></span></span></span></span><br>
<span style="font-size:10pt"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt"><span style="color:black">Conclusion:</span></span></b> <span lang="EN-CA" style="font-size:11.0pt"><span style="color:black">South Khorasan Province demonstrated a high incidence of CH. Given the important role of this disorder in intellectual disability, further studies are needed to identify the factors contributing to its high occurrence.</span></span></span></span></div>
کمکاری مادرزادی تیروئید, نوزاد, غربالگری, خراسان جنوبی
Congenital hypothyroidism, Newborn, Screening, South Khorasan
0
0
http://journal.bums.ac.ir/browse.php?a_code=A-10-2022-2&slc_lang=en&sid=1
Alireza
Taleb
علیرضا
طالب
alijzjzzj@gmail.com
8700319475328460051883
0009-0003-1067-0251
No
Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
دانشکده پزشکی دانشگاه علوم پزشکی بیرجند، بیرجند، ایران
Hossein
Hatamikia
حسین
حاتمیکیا
h.hatameikya@bums.ac.ir
8700319475328460051884
8700319475328460051884
No
Deputy Director of Health, Birjand University of Medical Sciences, Birjand, Iran
معاونت بهداشتی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران
Kokab
Namakin
کوکب
نمکین
dr.namakin@gmail.com
8700319475328460051885
8700319475328460051885
No
Department of Pediatrics, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
گروه اطفال، دانشکده پزشکی، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران
Ebrahim
Miri-Moghaddam
ابراهیم
میری مقدم
miri4@bums.ac.ir
8700319475328460051886
8700319475328460051886
Yes
Department of Molecular Medicine, Faculty of Medicine, Cardiovascular Research Center, Birjand University of Medical Sciences, Birjand, Iran
گروه پزشکی مولکولی، دانشکده پزشکی، مرکز تحقیقات بیماریهای قلبوعروق، دانشگاه علوم پزشکی بیرجند، بیرجند، ایران